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Publications Reporting Intratracheal Administration

Publications Reporting Intratracheal Delivery of Clodronate Liposomes

Including Intratracheal Instillation and Intratracheal Injection

  1. A.D. Dorr, M.R. Wilson, K. Wakabayashi, A.C. Waite, B.V. Patel, N. van Rooijen, K.P. O’Dea, M. Takata, Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies, Journal of Applied Physiology, 111 (2011) 177–184.
  2. S. Bhatia, M. Fei, M. Yarlagadda, Z. Qi, S. Akira, S. Saijo, Y. Iwakura, N. van Rooijen, G.A. Gibson, C.M. St. Croix, A. Ray, P. Ray, Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype, PLoS ONE, 6 (2011) e15943.
  3. K. El Bakkouri, F. Descamps, M. De Filette, A. Smet, E. Festjens, A. Birkett, N. Van Rooijen, S. Verbeek, W. Fiers, X. Saelens, Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection, The Journal of Immunology, 186 (2011) 1022.
  4. D. Iwami, Q. Zhang, O. Aramaki, K. Matsuno, K. Nonomura, N. Shirasugi, M. Niimi, Depletion of Alveolar Macrophages Abrogates Prolongation of Cardiac Allograft Survival Induced by Intratracheal Delivery of Alloantigen, Transplantation, (2010) 1.
  5. J.J. Li, W. Wang, K.J. Baines, N.A. Bowden, P.M. Hansbro, P.G. Gibson, R.K. Kumar, P.S. Foster, M. Yang, IL-27/IFN-γ Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages, The Journal of Immunology, 185 (2010) 4401–4409.
  6. D.R. Nagarkar, E.R. Bowman, D. Schneider, Q. Wang, J. Shim, Y. Zhao, M.J. Linn, C.L. McHenry, B. Gosangi, J.K. Bentley, W.C. Tsai, U.S. Sajjan, N.W. Lukacs, M.B. Hershenson, Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages, The Journal of Immunology, 185 (2010) 2525–2535.
  7. F. Venet, X. Huang, C.-S. Chung, Y. Chen, A. Ayala, Plasmacytoid Dendritic Cells Control Lung Inflammation and Monocyte Recruitment in Indirect Acute Lung Injury in Mice, The American Journal of Pathology, 176 (2010) 764–773.
  8. D. Bedoret, H. Wallemacq, T. Marichal, C. Desmet, F. Quesada Calvo, E. Henry, R. Closset, B. Dewals, C. Thielen, P. Gustin, L. de Leval, N. Van Rooijen, A. Le Moine, A. Vanderplasschen, D. Cataldo, P.-V. Drion, M. Moser, P. Lekeux, F. Bureau, Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice, Journal of Clinical Investigation, 119 (2009) 3723–3738.
  9. M. Yang, R.K. Kumar, P.S. Foster, Interferon-γ and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness, Clinical & Experimental Allergy, (2009).
  10. M.M. Mircescu, L. Lipuma, N. van Rooijen, E.G. Pamer, T.M. Hohl, Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points following Aspergillus fumigatus Infection, The Journal of Infectious Diseases, 200 (2009) 647–656.
  11. W. Han, M. Joo, M.B. Everhart, J.W. Christman, F.E. Yull, T.S. Blackwell, Myeloid cells control termination of lung inflammation through the NF-κB pathway, AJP: Lung Cellular and Molecular Physiology, 296 (2009) L320–L327.
  12. T. Traeger, W. Kessler, A. Hilpert, M. Mikulcak, M. Entleutner, P. Koerner, A. Westerholt, K. Cziupka, N. van Rooijen, C.-D. Heidecke, S. Maier, Selective Depletion of Alveolar Macrophages in Polymicrobial Sepsis Increases Lung Injury, Bacterial Load and Mortality but Does Not Affect Cytokine Release, Respiration, 77 (2009) 203–213.
  13. R.A. Bem, A.W. Farnand, V. Wong, A. Koski, M.E. Rosenfeld, N. van Rooijen, C.W. Frevert, T.R. Martin, G. Matute-Bello, Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice, American Journal of Physiology – Lung Cellular and Molecular Physiology, 295 (2008) L314–L325.
  14. L.B. Moraes, A.H.F. Murakami, B. Fontes, R.S. Poggetti, N. van Rooijen, R.N. Younes, A.M.C. Heimbecker, D. Birolini, Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event, Journal of Trauma, 64 (2008) 1196–1200; discussion 1200–1201.
  15. G.T. Stathopoulos, T.P. Sherrill, W. Han, R.T. Sadikot, F.E. Yull, T.S. Blackwell, B. Fingleton, Host nuclear factor-kappaB activation potentiates lung cancer metastasis, Molecular Cancer Research, 6 (2008) 364–371.
  16. P. Pouliot, A. Spahr, é. Careau, V. Turmel, E.Y. Bissonnette, Alveolar macrophages from allergic lungs are not committed to a pro-allergic response and can reduce airway hyperresponsiveness following ex vivo culture, Clinical & Experimental Allergy, 38 (2008) 529–538.
  17. N.C. Gonzalez, J. Allen, V.G. Blanco, E.J. Schmidt, N. van Rooijen, J.G. Wood, Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia, Journal of Applied Physiology, 103 (2007) 1386–1394.
  18. M. Chignard, V. Balloy, J.-M. Sallenave, M. Si-Tahar, Role of Toll-like receptors in lung innate defense against invasive aspergillosis Distinct impact in immunocompetent and immunocompromized hosts, Clinical Immunology, 124 (2007) 238–243.
  19. R. Rivera, M. Hutchens, K.E. Luker, J. Sonstein, J.L. Curtis, G.D. Luker, Murine alveolar macrophages limit replication of vaccinia virus, Virology, 363 (2007) 48–58.
  20. A. Forbes, M. Pickell, M. Foroughian, L.-J. Yao, J. Lewis, R. Veldhuizen, Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats, Journal of Applied Physiology, 103 (2007) 637–645.
  21. F.G. Eyal, C.R. Hamm, J.C. Parker, Reduction in alveolar macrophages attenuates acute ventilator induced lung injury in rats, Intensive Care Medicine, 33 (2007) 1212–1218.
  22. R. Zhou, J.E. Norton, N. Zhang, D.A. Dean, Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation, Gene Therapy, 14 (2007) 775–780.
  23. G.M. Mutlu, D. Green, A. Bellmeyer, C.M. Baker, Z. Burgess, N. Rajamannan, J.W. Christman, N. Foiles, D.W. Kamp, A.J. Ghio, N.S. Chandel, D.A. Dean, J.I. Sznajder, G.R.S. Budinger, Ambient particulate matter accelerates coagulation via an IL-6–dependent pathway, The Journal of Clinical Investigation, 117 (2007) 2952.
  24. M. Zhao, L.G. Fernandez, A. Doctor, A.K. Sharma, A. Zarbock, C.G. Tribble, I.L. Kron, V.E. Laubach, Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury, American Journal of Physiology – Lung Cellular and Molecular Physiology, 291 (2006) L1018 –L1026.
  25. K.S. Farley, L.F. Wang, H.M. Razavi, C. Law, M. Rohan, D.G. McCormack, S. Mehta, Effects of Macrophage Inducible Nitric Oxide Synthase in Murine Septic Lung Injury,  American Journal of Physiology – Lung Cellular and Molecular Physiology, 290 (2006) L1164–L1172.
  26. D. Valstar, M. Schijf, J. Arts, C. Kuper, F. Nijkamp, G. Storm, N. Bloksma, P. Henricks, Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin, Archives of Toxicology, 80 (2006) 561–571.
  27. J.A. Frank, C.M. Wray, D.F. McAuley, R. Schwendener, M.A. Matthay, Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury, American Journal of Physiology-Lung Cellular and Molecular Physiology, 291 (2006) L1191–L1198.
  28. H.B. Acuff, K.J. Carter, B. Fingleton, D.L. Gorden, L.M. Matrisian, Matrix Metalloproteinase-9 from Bone Marrow–Derived Cells Contributes to Survival but not Growth of Tumor Cells in the Lung Microenvironment, Cancer Research, 66 (2006) 259.
  29. C.M. Bosio, S.W. Dow, Francisella tularensis Induces Aberrant Activation of Pulmonary Dendritic Cells, The Journal of Immunology, 175 (2005) 6792 –6801.
  30. D. Vuichard, M.T. Ganter, R.C. Schimmer, D. Suter, C. Booy, L. Reyes, T. Pasch, B. Beck‐Schimmer, Hypoxia aggravates lipopolysaccharide‐induced lung injury, Clinical & Experimental Immunology, 141 (2005) 248–260.
  31. B. Beck-Schimmer, R. Schwendener, T. Pasch, L. Reyes, C. Booy, R.C. Schimmer, Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury, Respiratory Research, 6 (2005) 61.
  32. A. Nemmar, B. Nemery, P.H.M. Hoet, N. van Rooijen, M.F. Hoylaerts, Silica Particles Enhance Peripheral Thrombosis: Key Role of Lung Macrophage-Neutrophil Cross-Talk, American Journal of Respiratory and Critical Care Medicine, 171 (2005) 872–879.
  33. T. Nakamura, R. Abu-Dahab, M.D. Menger, U. Schäfer, B. Vollmar, H. Wada, C.-M. Lehr, H.-J. Schäfers, Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia—reperfusion injury of the lung, The Journal of Heart and Lung Transplantation, 24 (2005) 38–45.
  34. J. Skokowa, S.R. Ali, O. Felda, V. Kumar, S. Konrad, N. Shushakova, R.E. Schmidt, R.P. Piekorz, B. Nürnberg, K. Spicher, L. Birnbaumer, J. Zwirner, J.W.C. Claassens, J.S. Verbeek, N. van Rooijen, J. Köhl, J.E. Gessner, Macrophages induce the inflammatory response in the pulmonary Arthus reaction through Gαi2 activation that controls C5aR and Fc receptor cooperation, The Journal of Immunology, 174 (2005) 3041.
  35. X. Shao, A. Mednick, M. Alvarez, N. van Rooijen, A. Casadevall, D.L. Goldman, An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia, The Journal of Immunology, 175 (2005) 3244.
  36. M.B. Everhart, W. Han, K.S. Parman, V.V. Polosukhin, H. Zeng, R.T. Sadikot, B. Li, F.E. Yull, J.W. Christman, T.S. Blackwell, Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation, Journal of Leukocyte Biology, 77 (2005) 173–180.
  37. C.M. Bosio, A.W. Goodyear, S.W. Dow, Early interaction of Yersinia pestis with APCs in the lung, The Journal of Immunology, 175 (2005) 6750.
  38. H. Gao, R.-F. Guo, C.L. Speyer, J. Reuben, T.A. Neff, L.M. Hoesel, N.C. Riedemann, S.D. McClintock, J.V. Sarma, N. Van Rooijen, F.S. Zetoune, P.A. Ward, Stat3 Activation in Acute Lung Injury, The Journal of Immunology, 172 (2004) 7703–7712.
  39. B.V. Naidu, B. Krishnadasan, A.S. Farivar, S.M. Woolley, R. Thomas, N. Van Rooijen, E.D. Verrier, M.S. Mulligan, Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury, The Journal of Thoracic and Cardiovascular Surgery, 126 (2003) 200–207.
  40. U.A. Maus, K. Waelsch, W.A. Kuziel, T. Delbeck, M. Mack, T.S. Blackwell, J.W. Christman, D. Schlöndorff, W. Seeger, J. Lohmeyer, Monocytes Are Potent Facilitators of Alveolar Neutrophil Emigration During Lung Inflammation: Role of the CCL2-CCR2 Axis,  The Journal of Immunology, 170 (2003) 3273–3278.
  41. C. Madjdpour, U.R. Jewell, S. Kneller, U. Ziegler, R. Schwendener, C. Booy, L. Kläusli, T. Pasch, R.C. Schimmer, B. Beck-Schimmer, Decreased alveolar oxygen induces lung inflammation, American Journal of Physiology – Lung Cellular and Molecular Physiology, 284 (2003) L360–L367.
  42. H.A. Haeberle, R. Takizawa, A. Casola, A.R. Brasier, H.-J. Dieterich, N. Van Rooijen, Z. Gatalica, R.P. Garofalo, Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways, Journal of Infectious Disease, 186 (2002) 1199–1206.
  43. R.-F. Guo, A.B. Lentsch, J.V. Sarma, L. Sun, N.C. Riedemann, S.D. McClintock, S.R. McGuire, N. Van Rooijen, P.A. Ward, Activator Protein-1 Activation in Acute Lung Injury, The American Journal of Pathology, 161 (2002) 275–282.
  44. U.A. Maus, M.A. Koay, T. Delbeck, M. Mack, M. Ermert, L. Ermert, T.S. Blackwell, J.W. Christman, D. Schlöndorff, W. Seeger, J. Lohmeyer, Role of Resident Alveolar Macrophages in Leukocyte Traffic into the Alveolar Air Space of Intact Mice, American Journal of Physiology – Lung Cellular and Molecular Physiology, 282 (2002) L1245–L1252.
  45. L. Salez, V. Balloy, N. van Rooijen, M. Lebastard, L. Touqui, F.X. McCormack, M. Chignard, Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages,  The Journal of Immunology, 166 (2001) 6376–6382.
  46. J. Zhang-Hoover, A. Sutton, N. Van Rooijen, J. Stein-Streilein, A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis, Immunology, 101 (2000) 501–511.
  47. R.L. Kradin, H.-W. Liu, N. Van ROOIJEN, K. Springer, L.-H. Zhao, C.P. Leary, Pulmonary Immunity to Listeria Is Enhanced by Elimination of Alveolar Macrophages, American Journal of Respiratory and Critical Care Medicine, 159 (1999) 1967–1974.
  48. G.A.P. Nieuwenhuijzen, M.F.C.M. Knapen, T. Hendriks, N. van Rooijen, R.J.A. Goris, Elimination of Various Subpopulations of Macrophages and the Development of Multiple-Organ Dysfunction Syndrome in Mice, Archives of  Surgery, 132 (1997) 533–539.
  49. J.M. Hickman-Davis, S.M. Michalek, J. Gibbs-Erwin, J.R. Lindsey, Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H mice, Infection and Immunity, 65 (1997) 2278.
  50. T. Suda, R.J. Callahan, R.A. Wilkenson, N. van Rooijen, E.E. Schneeberger, Interferon-gamma reduces Ia+ dendritic cell traffic to the lung, Journal of Leukocyte Biology, 60 (1996) 519 –527.
  51. J.T. Berg, S.T. Lee, T. Thepen, C.Y. Lee, M.F. Tsan, Depletion of alveolar macrophages by liposome-encapsulated dichloromethylene diphosphonate, Journal of Applied Physiology, 74 (1993) 2812 –2819.

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