Used for…
- Assessing the effect of liposomes alone on target phagocytes in m-Clodrosome studies (liposome control)
- Determining if unexpected results are due to the presence of liposomes rather than clodronate
- Pretreating to accomplish RES loading which will dramatically alter the distribution and circulation time of subsequently dosed m-Clodrosome
- Mixing with unencapsulated clodronate to assess the effect of free clodronate in the presence of liposomes
Mannosylated control liposomes
| Contains: | mg/ml | mM | |
|---|---|---|---|
| L-α-Phosphatidylcholine | 18.8 | 24 | |
| Cholesterol | 4.2 | 11 | |
| 4-Aminophenyl-alpha-D-Mannopyranoside | 1 | 3.69 | |
| Suspended in Phosphate Buffered Saline at pH 7.4 | |||
See Encapsome Product Description for complete listing of Encapsome properties.
» Surface-modified with branched-chain oligomannose for optimal recognition by mannose-receptors (MR, SIGNR1)
» Lipid composition is biosimilar egg-phosphatidylcholine and cholesterol in a 7:3 molar ratio
» Optimal size range (0.3-3 µm) for immediate phagocyte recognition and phagocytosis
» Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
» Prepared and packaged under sterile conditions in 5 ml stoppered glass vials with multidose adapters
» Batches prepared weekly to ensure maximal shelf-life after receipt by client
» Available as single product or in convenient Mannosylated Macrophage Depletion Kits
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