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Fluoroliposome-DiO

 

Fluoroliposome®-DiO (fluorescent control liposomes).

Fluoroliposome®-DiO (fluorescent control liposomes).

Contains: mg/ml mM
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
DiO (lipophilic fluorescent dye: ex/em~484/501 nm) 0.0625 0.071
Suspended in Phosphate Buffered Saline at pH 7.4

 

 

 

DiO emission ext

 

 

 

 

 

DiO structure

 

 

 

 


» Prepared identically to Clodrosome except no clodronate is added and fluorophore is incorporated
» Serves as Clodrosome control because phagocytes can respond immunologically to liposome uptake
» Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
» Prepared and packaged under sterile conditions
» Some DiO advantages…

  • Incorporates into the liposome bilayer, therefore liposome remains fluorescent until bilayer structure is completely dissembled even when liposome contents are released
  • Does not readily exchange out of liposomes into cell membranes or other lipid-containing structures (HDL, etc.)
  • Detectable by, and functions in, all fluorescence methods (fluoroscopy, fluorescence resonance energy transfer (FRET), etc.) using a rhodamine filter
  • Minimal  fluorescence in aqueous phase, but high yield when incorporated into lipid bilayers
  • DiO liposomes are highly visible to the naked eye even in small quantities
  • Comprehensive description of DiO from the Molecular Probes Handbook at invitrogen.com
  • See FAQ (Question 1) for more information on the use of fluorescent liposomes.

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Contact

Encapsula NanoSciences LLC
6 Cadillac Dr
Suite 245
Brentwood, TN 37027
Phone: 1-800-387-0620
Phone: 1-800-401-5140
Fax: 615-250-8747
URL: www.encapsula.com
email: info@encapsula.com

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