Use instead of Clodrosome when…

  • Target phagocyte subset is not being sufficiently depleted by standard Clodrosome
  • Target phagocytes are known to express a mannose receptor (MR, MMR or CD206) or SIGNR1

 

Contains: mg/ml mM
Clodronate Disodium Salt 5 17
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
Man3-Glutaryl-Phosphatidylethanolamine 2.1 1.8
Suspended in Phosphate Buffered Saline at pH 7.4
Clodronate Structure

See Clodrosome Product Description for complete listing of clodronate properties.

 

Man3-glu-DPPEMan3-glutaryl-phosphatidylethanolamine is the phospholipid derivative which displays the branched mannose structure on the surface of the liposome.


» Surface-modified with branched-chain oligomannose for optimal recognition by mannose-receptors (MR, SIGNR1)
» Lipid composition is biosimilar egg-phosphatidylcholine and cholesterol in a 7:3 molar ratio
» Optimal size range (0.3-3 µm) for immediate phagocyte recognition and phagocytosis
» Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
» Prepared and packaged under sterile conditions in 5 ml stoppered glass vials with multidose adapters
» Batches prepared weekly to ensure maximal shelf-life after receipt by client
» Available as single product or in convenient Mannosylated Macrophage Depletion Kits


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