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Publications Reporting Intranasal Administration (Intrapulmonary)

Publications Reporting Intranasal Delivery of Clodronate Liposomes to the Lungs

  1. V.I. Ayala, J.R. Teijaro, D.L. Farber, S.G. Dorsey, N.H. Carbonetti, Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin-Mediated Suppression of Innate Immunity, PLoS ONE, 6 (2011) e19016.
  2. A.S. Borders, M.L. Getchell, J.T. Etscheidt, N. van Rooijen, D.A. Cohen, T.V. Getchell, Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis, The Journal of Comparative Neurology, 501 (2007) 206–218.
  3. N.H. Carbonetti, G.V. Artamonova, N. Van Rooijen, V.I. Ayala, Pertussis Toxin Targets Airway Macrophages To Promote Bordetella pertussis Infection of the Respiratory Tract, Infection and Immunity, 75 (2007) 1713–1720.
  4. E. Claudio, S.U. Sønder, S. Saret, G. Carvalho, T.R. Ramalingam, T.A. Wynn, A. Chariot, A. Garcia-Perganeda, A. Leonardi, A. Paun, A. Chen, N.Y. Ren, H. Wang, U. Siebenlist, The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation, The Journal of Immunology, 182 (2009) 1617 –1630.
  5. C.K. Cote, K.M. Rea, S.L. Norris, N. van Rooijen, S.L. Welkos, The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores, Microbial Pathogogens, 37 (2004) 169–175.
  6. C.K. Cote, N. Van Rooijen, S.L. Welkos, Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection,  American Journal of Respiratory and Critical Care Medicine, 74 (2006) 469–480.
  7. D.H. Dockrell, H.M. Marriott, L.R. Prince, V.C. Ridger, P.G. Ince, P.G. Hellewell, M.K.B. Whyte, Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection, The Journal of Immunology, 171 (2003) 5380 –5388.
  8. E.M. Goebel, D.N. Wolfe, K. Elder, S. Stibitz, E.T. Harvill, O Antigen Protects Bordetella parapertussis from Complement, Infection and Immunity, 76 (2008) 1774–1780.
  9. A. Guerrero, N. Jain, X. Wang, B.C. Fries, Cryptococcus Neoformans Variants Generated by Phenotypic Switching Differ in Virulence Through Effects on Macrophage Activation,  Infection and Immunity, 78 (2010) 1049–1057.
  10. H.A. Haeberle, R. Takizawa, A. Casola, A.R. Brasier, H.-J. Dieterich, N. Van Rooijen, Z. Gatalica, R.P. Garofalo, Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways, Journal of  Infectious Disease, 186 (2002) 1199–1206.
  11. F.-F. Huang, P.F. Barnes, Y. Feng, R. Donis, Z.C. Chroneos, S. Idell, T. Allen, D.R. Perez, J.A. Whitsett, K. Dunussi-Joannopoulos, H. Shams, GM-CSF in the Lung Protects Against Lethal Influenza Infection,  American Journal of Respiratory and Critical Care Medicine, 184 (2011) 259–268.
  12. O. Ibrahim-Granet, G. Jouvion, T. Hohl, S. Droin-Bergere, F. Philippart, O. Kim, M. Adib-Conquy, R. Schwendener, J.-M. Cavaillon, M. Brock, In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis, BMC Microbiology, 10 (2010) 105.
  13. C. Jakubzick, F. Tacke, J. Llodra, N. van Rooijen, G.J. Randolph, Modulation of dendritic cell trafficking to and from the airways,  The Journal of Immunology, 176 (2006) 3578–3584.
  14. T.B. Kechichian, J. Shea, M. Del Poeta, Depletion of Alveolar Macrophages Decreases the Dissemination of a Glucosylceramide-Deficient Mutant of Cryptococcus neoformans in Immunodeficient Mice, Infection and Immunity, 75 (2007) 4792–4798.
  15. H.M. Kim, Y.-W. Lee, K.-J. Lee, H.S. Kim, S.W. Cho, N. van Rooijen, Y. Guan, S.H. Seo, Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs, Journal of Virology, 82 (2008) 4265–4274.
  16. G.S. Kirimanjeswara, J.M. Golden, C.S. Bakshi, D.W. Metzger, Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis, The Journal of Immunology, 179 (2007) 532.
  17. S. Knapp, M.J. Schultz, T. van der Poll, Pneumonia Models and Innate Immunity To Respiratory Bacterial Pathogens, Shock, 24 (2005).
  18. A.Y. Koh, G.P. Priebe, C. Ray, N. Van Rooijen, G.B. Pier, Inescapable Need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia, Infection and Immunity, 77 (2009) 5300–5310.
  19. E. Kostina, I. Ofek, E. Crouch, R. Friedman, L. Sirota, G. Klinger, H. Sahly, Y. Keisari, Noncapsulated Klebsiella pneumoniae Bearing Mannose-Containing O Antigens Is Rapidly Eradicated from Mouse Lung and Triggers Cytokine Production by Macrophages following Opsonization with Surfactant Protein D, Infection and Immunity, 73 (2005) 8282 –8290.
  20. M. Kurowska-Stolarska, B. Stolarski, P. Kewin, G. Murphy, C.J. Corrigan, S. Ying, N. Pitman, A. Mirchandani, B. Rana, N. van Rooijen, M. Shepherd, C. McSharry, I.B. McInnes, D. Xu, F.Y. Liew, IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation, The Journal of Immunology, 183 (2009) 6469–6477.
  21. A.M. Lee, A.D. Fryer, N. Vanrooijen, D.B. Jacoby, Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction,  American Journal of Pathology: Regulatory, Integrative and Comparative Physiology, 286 (2004) L1255–L1259.
  22. J.C. Leemans, N.P. Juffermans, S. Florquin, N. van Rooijen, M.J. Vervoordeldonk, A. Verbon, S.J. van Deventer, T. van der Poll, Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice,  The Journal of Immunology, 166 (2001) 4604–4611.
  23. J.C. Leemans, Pulmonary Immune Responses during (Myco)bacterial Infection, Thesis (PhD), University of Amsterdam, 2002.
  24. A.M. Manicone, T.P. Birkland, M. Lin, T. Betsuyaku, N. Van Rooijen, J. Lohi, J. Keski-Oja, Y. Wang, S.J. Skerrett, W.C. Parks, Epilysin (MMP-28) Restrains Early Macrophage Recruitment in Pseudomonas Aeruginosa Pneumonia,  The Journal of Immunology, 182 (2009) 3866–3876.
  25. F.J. Martin, D. Parker, B.S. Harfenist, G. Soong, A. Prince, Participation of CD11c+ Leukocytes in Methicillin-Resistant Staphylococcus aureus Clearance from the Lung, Infection and Immunity, 79 (2011) 1898–1904.
  26. J. McGill, N. Van Rooijen, K.L. Legge, Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs, Journal of Experimental Medicine, 205 (2008) 1635–1646.
  27. J.L. McGill, The role of pulmonary dendritic cells in regulating the antigen-specific CD8 T cell response following influenza virus infection, Dissertation, 2010.
  28. J. McGill, N. Van Rooijen, K.L. Legge, IL-15 Trans-Presentation by Pulmonary Dendritic Cells Promotes Effector CD8 T Cell Survival During Influenza Virus Infection, Journal of Experimental Medicine, 207 (2010) 521–534.
  29. E.A. Murphy, J.M. Davis, A.S. Brown, M.D. Carmichael, J.A. Carson, N. Van Rooijen, A. Ghaffar, E.P. Mayer, Benefits of oat  β-glucan on respiratory infection following exercise stress: role of lung macrophages, American Journal of Pathology: Regulatory, Integrative and Comparative Physiology, 294 (2008) R1593–R1599.
  30. E.A. Murphy, J.M. Davis, A.S. Brown, M.D. Carmichael, N. van Rooijen, A. Ghaffar, E.P. Mayer, Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training, American Journal of Pathology: Regulatory, Integrative and Comparative Physiology, 287 (2004) R1354–R1358.
  31. A.P. Phadke, G. Akangire, S.J. Park, S.A. Lira, B. Mehrad, The Role of CC Chemokine Receptor 6 in Host Defense in a Model of Invasive Pulmonary Aspergillosis, American Journal of Respiratory and Critical Care Medicine, 175 (2007) 1165–1172.
  32. P.K. Pribul, J. Harker, B. Wang, H. Wang, J.S. Tregoning, J. Schwarze, P.J.M. Openshaw, Alveolar Macrophages Are a Major Determinant of Early Responses to Viral Lung Infection but Do Not Influence Subsequent Disease Development, Journal of Virology, 82 (2008) 4441–4448.
  33. H. Qiu, Y. Fan, A.G. Joyee, S. Wang, X. Han, H. Bai, L. Jiao, N. Van Rooijen, X. Yang, Type I IFNs Enhance Susceptibility to Chlamydia Muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages, The Journal of Immunology, 181 (2008) 2092–2102.
  34. J.L. Reed, Y.A. Brewah, T. Delaney, T. Welliver, T. Burwell, E. Benjamin, E. Kuta, A. Kozhich, L. McKinney, J. Suzich, P.A. Kiener, L. Avendano, L. Velozo, A. Humbles, R.C. Welliver, A.J. Coyle, Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis,  Journal of Infectious Disease, 198 (2008) 1783–1793.
  35. B. Roscic-Mrkic, R.A. Schwendener, B. Odermatt, A. Zuniga, J. Pavlovic, M.A. Billeter, R. Cattaneo, Roles of macrophages in measles virus infection of genetically modified mice, Journal of Virology, 75 (2001) 3343–3351.
  36. C. Schnoeller, S. Rausch, S. Pillai, A. Avagyan, B.M. Wittig, C. Loddenkemper, A. Hamann, E. Hamelmann, R. Lucius, S. Hartmann, A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages,  The Journal of Immunology, 180 (2008) 4265–4272.
  37. L.M. Sedger, S. Hou, S.R. Osvath, M.B. Glaccum, J.J. Peschon, N. van Rooijen, L. Hyland, Bone Marrow B Cell Apoptosis During In Vivo Influenza Virus Infection Requires TNF-α and Lymphotoxin-α, The Journal of Immunology, 169 (2002) 6193 –6201.
  38. T. Sheahan, T.E. Morrison, W. Funkhouser, S. Uematsu, S. Akira, R.S. Baric, M.T. Heise, MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV, PLoS Pathogens, 4 (2008) e1000240.
  39. J.-M. Song, B.-Z. Wang, K.-M. Park, N. Van Rooijen, F.-S. Quan, M.-C. Kim, H.-T. Jin, A. Pekosz, R.W. Compans, S.-M. Kang, Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity, PLoS ONE, 6 (2011) e14538.
  40. K. Sun, D.W. Metzger, Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection, Nature Medicine, 14 (2008) 558–564.
  41. C. Tang, M.D. Inman, N. van Rooijen, P. Yang, H. Shen, K. Matsumoto, P.M. O’Byrne, Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism, The Journal of Immunology, 166 (2001) 1471 –1481.
  42. M.D. Tate, D.L. Pickett, N. van Rooijen, A.G. Brooks, P.C. Reading, Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice,  Journal of  Virology , 84 (2010) 7569–7580.
  43. T.M. Tumpey, A. García-Sastre, J.K. Taubenberger, P. Palese, D.E. Swayne, M.J. Pantin-Jackwood, S. Schultz-Cherry, A. Solórzano, N. Van Rooijen, J.M. Katz, C.F. Basler, Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice,  Journal of  Virology , 79 (2005) 14933–14944.
  44. J. Wang, R.A. Barke, R. Charboneau, R. Schwendener, S. Roy, Morphine Induces Defects in Early Response of Alveolar Macrophages to Streptococcus Pneumoniae by Modulating TLR9-NF-κB Signaling,  The Journal of Immunology, 180 (2008) 3594–3600.
  45. O.L. Wijburg, S. DiNatale, J. Vadolas, N. Van Rooijen, R.A. Strugnell, Alveolar Macrophages Regulate the Induction of Primary Cytotoxic T-Lymphocyte Responses During Influenza Virus Infection, Journal of  Virology , 71 (1997) 9450–9457.
  46. Z. Zhang, T.B. Clarke, J.N. Weiser, Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice, Journal of Clinical Investigation, 119 (2009) 1899–1909.
  47. J. Zhang-Hoover, A. Sutton, N. Van Rooijen, J. Stein-Streilein, A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis, Immunology, 101 (2000) 501–511.
  48. J. Zhao, J. Zhao, N. Van Rooijen, S. Perlman, Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice, PLoS Pathogens, 5 (2009) e1000636.

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