Mannosylated Clodrosome Macrophage Depletion Reagents
- Unmodified multilamellar clodronate-containing and control liposomes
- Composed of biosimilar egg-derived phophatidylcholine and cholesterol in a 7:3 molar ratio
- 4-Aminophenyl-alpha-D-
Mannopyranoside incorporated into the liposomes - Suspended in physiologically-compatible Phosphate Buffered Saline (PBS) at pH 7.4
- Similar to formulations used in majority of published macrophage depletion studies
- Optimal size (0.3-3 µm) for rapid macrophage uptake
- May be dosed systemically or locally (see Routes of Administration )
- Use Fluoroliposome™ (fluorescent control liposomes) for FACS analysis, confocal microscopy and biodistribution
- See the FAQ page for more information on the use of fluorescent liposomes in macrophage depletion studies
- Purchase individual reagents or select a Macrophage Depletion Kit as shown below
Mannosylated Macrophage Depletion Kit
The Mannosylated Macrophage Depletion Kit contains m-Clodrosome® (liposomal clodronate) and m-Encapsome® (control liposomes).
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Mannosylated Fluorescent-DiI Macrophage Depletion Kit
The Mannosylated Fluorescent Macrophage Depletion Kit contains mClodrosome® (liposomal clodronate) and m-Fluoroliposome®-DiI (fluorescent control liposomes).
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Mannosylated Fluorescent-DiO Macrophage Depletion Kit
The Mannosylated Fluorescent Macrophage Depletion Kit contains m-Clodrosome® (liposomal clodronate) and m-Fluoroliposome®-DiO (fluorescent control liposomes).
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Mannosylated Fluorescent-DiD Macrophage Depletion Kit
The Mannosylated Fluorescent Macrophage Depletion Kit contains m-Clodrosome® (liposomal clodronate) and m-Fluoroliposome®-DiD (fluorescent control liposomes).
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Full Manosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiI

The kit contains one vial of m-Clodrosome, one vial of m-Encapsome, and one vial of m-Fluoroliposome-DiI
The Full Mannosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiI contains m-Clodrosome® (liposomal clodronate), m-Encapsome® (control liposomes), and m-Fluoroliposome®-DiI (fluorescent control liposomes).
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Full Mannosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiO
- The Full Mannosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiO contains m-Clodrosome® (liposomal clodronate), m-Encapsome® (control liposomes), and m-Fluoroliposome®-DiO (fluorescent control liposomes).
Full Mannosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiD

The kit contains one vial of m-Clodrosome, one vial of m-Encapsome, and one vial of m-Fluoroliposome-DiD
The Full Mannosylated Macrophage Depletion Kit with m-Fluoroliposome®-DiD contains m-Clodrosome® (liposomal clodronate), m-Encapsome® (control liposomes), and m- Fluoroliposome®-DiD (fluorescent control liposomes).
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