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Standard Macrophage Depletion Kits

Clodrosome Macrophage Depletion Kits

  • Contain unmodified multilamellar liposomes similar to those used in most published depletion studies
  • Liposome size range (0.3-3 µm) is optimal for immediate phagocyte recognition and uptake
  • Kits contain equal volumes of each reagent packaged in stoppered glass vials with multidose vial adapters
  • Select the Fluorescent Kit to visualize control liposomes in vitro or in vivo

Each Clodrosome Macrophage Depletion Kit contains Clodrosome and an equal volume of control liposomes.

Further details on each reagent is available by clicking on “More Info” below its image.


Clodrosome® (Liposomal Clodronate)

Clodrosome® (Liposomal Clodronate)

Clodrosome® (Liposomal Clodronate)

More Info
mg/ml mM
Clodronate Disodium Salt 5 17
L-α-Phosphatidylcholine 18.8  24
Cholesterol  4.2  11
Suspended in Phosphate Buffered Saline at pH 7.4
  • Clodronate encapsulated inside multilamellar liposome aqueous spaces
  • Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
  • Prepared and packaged under sterile conditions

Control liposomes complete the Clodrosome Macrophage Depletion Kit.

Select either Encapsome control liposomes (Standard Clodrosome Kit) or

Fluoroliposome fluorescent control liposomes (Fluorescent Clodrosome Kit) described below.

See FAQ (Question 1) for more information on the use of fluorescent liposomes.


Encapsome® (Control Liposomes)

Encapsome® (control liposomes)

Encapsome® (control liposomes)

More Info
mg/ml mM
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
Suspended in Phosphate Buffered Saline at pH 7.4
  • Prepared identically to Clodrosome except that clodronate is not added
  • Required control since phagocytes can respond to liposome uptake
  • Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
  • Prepared and packaged under sterile conditions

Fluoroliposome®-DiI (Fluorescent Control Liposomes)

Fluoroliposome®-DiI (fluorescent control liposomes).

Fluoroliposome®-DiI (fluorescent control liposomes).

More Info
mg/ml mM
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
DiI (lipophilic fluorescent dye: ex/em~550/580 nm) 0.0625 0.065
Suspended in Phosphate Buffered Saline at pH 7.4
  • Prepared identically to Clodrosome (without clodronate; with fluorophore)
  • Required control since phagocytes can respond to liposome uptake
  • May be tracked by fluorescence methods (confocal microscopy, FACS, etc.)
  • Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
  • Prepared and packaged under sterile conditions

Fluoroliposome®-DiO (Fluorescent Control Liposomes)

Fluoroliposome®-DiO (fluorescent control liposomes).

Fluoroliposome®-DiO (fluorescent control liposomes).

 More Info

mg/ml mM
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
DiO (lipophilic fluorescent dye: ex/em~484/501 nm) 0.0625 0.071
Suspended in Phosphate Buffered Saline at pH 7.4
  • Prepared identically to Clodrosome (without clodronate; with fluorophore)
  • Required control since phagocytes can respond to liposome uptake
  • May be tracked by fluorescence methods (confocal microscopy, FACS, etc.)
  • Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
  • Prepared and packaged under sterile conditions

Fluoroliposome®-DiD (Fluorescent Control Liposomes)

Fluoroliposome®-DiD (fluorescent control liposomes).

Fluoroliposome®-DiD (fluorescent control liposomes).

 

More Info
mg/ml mM
L-α-Phosphatidylcholine 18.8 24
Cholesterol 4.2 11
DiD (lipophilic fluorescent dye: ex/em~648/680 nm) 0.00625 0.0065
Suspended in Phosphate Buffered Saline at pH 7.4
  • Prepared identically to Clodrosome (without clodronate; with fluorophore)
  • Required control since phagocytes can respond to liposome uptake
  • May be tracked by fluorescence methods (confocal microscopy, FACS, etc.)
  • Extruded through 2 µm membranes to ensure that liposomes easily pass through lung capillaries
  • Prepared and packaged under sterile conditions

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Contact

Encapsula NanoSciences LLC
6 Cadillac Dr
Suite 245
Brentwood, TN 37027
Phone: 1-800-387-0620
Phone: 1-800-401-5140
Fax: 615-250-8747
URL: www.encapsula.com
email: info@encapsula.com

Copyright

Clodrosome®, Encapsome®, and Fluoroliposome® are trademarks of Encapsula NanoSciences. The content of the website can only be used by researchers, educators and students for educational purposes. Any commercial use of the content of the website is legally prohibited by the laws of the United States of America.

Disclaimer

All the products sold on the website are for research purposes only. Any use of these products in humans or animals/ pets for treatment purposes is legally prohibited by U S Food and Drug Administration.