Calandra T, Roger T.
Macrophage migration inhibitory factor: a regulator of innate immunity.
Nature Reviews Immunology. 2003 Oct 1;3(10):791–800.[toggle_content title=”Abstract”]
For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.[/toggle_content]